Tumore alla Prostata Metastatico: le nuove strategie con farmaci biologici e radiofarmaci
High-intensity focused ultrasound HIFU treatment has recently emerged in response to the increasing demand for noninvasive procedures for skin lifting and tightening. This study was aimed at evaluating the clinical efficacy of and patient satisfaction with HIFU treatment for wrinkles and laxity in seven different areas of the face in Asian skin. Twenty Korean patients with facial wrinkle and laxity were analyzed after a single session of HIFU treatment.
Two independent, blinded clinicians evaluated the clinical improvement in seven areas of the face by comparison of standardized photographs obtained before, and at 3 and 6 months after treatment. Assessment of subjective satisfaction and adverse effects of treatment were done by using questionnaires. The physicians' evaluation and patients' satisfaction with the clinical effects of HIFU in each area were similar regardless of the number of treatment shots.
The jawline, cheek, and perioral areas were the sites where HIFU was most effective, in decreasing order. The adverse effects included erythema and swelling in six cases, and purpura and bruising in two cases. However, the adverse effects were mild and High Intensity Focused Ultrasound per il cancro alla prostata. HIFU could be a safe, effective, and noninvasive procedure that can be used to improve facial wrinkles and skin laxity in Asian skin.
It is particularly effective for clinical improvement in the jawline, cheek, and perioral areas. Recently, there has been increasing public concern about facial wrinkles and loss of elasticity due to aging.
In response to this problem, various treatments, including chemical peeling, microdermabrasion, fractional laser, and radiofrequency, have been proposed for the treatment of facial wrinkles and laxity; however, the ideal treatment option has yet to be identified 1234.
Recently, ultrasound was introduced as a new treatment for therapeutic and cosmetic purposes 56. High-intensity focused ultrasound HIFU may be the best example of this technique. White et al. Currently, it is being used for facial rejuvenation, lifting, tightening, and body contouring, which are considered 'off-label' use 89 The principle of HIFU is to induce cellular damage and volume reduction of the target area selectively by means of coagulation by generating instant microthermal lesions through the accumulation of high-frequency ultrasound beams at the specific tissue site without any damage to the epidermis and adjacent issue In this study, we evaluated the clinical improvement, adverse effects, and patient satisfaction through the evaluation of clinical photographs and by using a questionnaire at 3 and 6 months after Ulthera treatment, in patients older than 30 years who desired facial lifting and wrinkle improvement.
Twenty patients with facial wrinkles and skin laxity were enrolled in the study. Informed consent was obtained from all patients, consisting of 18 women and 2 men. The patients' ages ranged from 37 to 75 years mean, We used hand pieces that delivered energy at 7.
In three patients, we used a nerve block of the supraorbital, supratrochlear, intraorbital, and mental nerves. After cleaning the face, a layer of ultrasound gel was applied to the skin. Each probe delivered a set of pulses in a linear array at 1-cm intervals. From to shots were delivered according to the size of the face. The clinical assessment was based on the evaluation of pretreatment and posttreatment photographs by two independent clinicians who were High Intensity Focused Ultrasound per il cancro alla prostata directly involved in the treatments.
They divided the face into seven areas supraorbital, zygomatic, infraorbital, perioral, cheek, preauricular, and jawline, High Intensity Focused Ultrasound per il cancro alla prostata the nose and periorbital areas. To assess the severity of facial wrinkles and skin laxity, we modified the eight-point photographic scale suggested by Chung et al.
The overall clinical improvement was also assessed. In addition, we conducted a survey to assess patient satisfaction and adverse effects. Each patient scored their satisfaction in each area of their faces, and also scored their overall satisfaction with their improvement after treatment on a scale of 1 to 5, as follows: 1, not satisfied; 2, somewhat satisfied; 3, satisfied; 4, very satisfied; 5, extremely satisfied.
We adjusted the order of the scale to make it easier to understand whether the treatment was effective or not. This questionnaire also included several questions about the patients' satisfaction after HIFU treatment, their assessment of adverse effects, and their opinions about whether they would like to undergo further HIFU treatment or whether they would recommend HIFU to others.
All p -values were two-tailed, and 0. This study included 20 Korean patients 18 women and 2 menaged 37 to 75 years mean, All patients showed clinical improvement after treatment compared with baseline.
Representative photos are shown in Fig. All seven areas showed clinical improvement at 3 and 6 months compared with baseline. The improvement was significant at 3 months after treatment, and efficacy was maintained throughout 6 months. The average wrinkle and skin laxity score decreased most in the jawline and periorbital areas Table 1Fig. On the surveys High Intensity Focused Ultrasound per il cancro alla prostata patient satisfaction by areas, the scores at 3 and 6 months were 3 or higher.
The jawline, perioral, and cheek areas showed the highest satisfaction scores. We observed that after 6 months, satisfaction decreased in all areas, except for the cheek area, which instead showed improvement Table 2Fig.
Answers to the question "Which area do you think showed the most improvement after Ulthera treatment? However, in a survey after 6 months, satisfaction in the cheek and perioral areas had somewhat increased compared with that in the jawline Fig.
We also assessed the efficacy and adverse effects 12 months after the treatment by means of a telephone interview or through e-mail. Among High Intensity Focused Ultrasound per il cancro alla prostata patients who replied, 4 patients answered that partial effects were still present in some areas. When we asked about adverse effects, there were six patients with erythema and swelling, and two patients with purpura and bruising.
However, these resolved within 2 weeks without any permanent complications Fig. No serious adverse events, including neuralgia, nerve palsy, severe edema lymphatic damageblistering, or fat atrophy were noted throughout the 6 months after treatment.
In addition, no long-term adverse effects were reported in the 15 patients who replied after 12 months. When we asked if patients wanted to receive more treatments and would recommend the treatment to others, most of them answered positively. However, one patient did not want retreatment because of unsatisfactory effectiveness, and two patients said they would not recommend the treatment to others because of the cost Fig. Both intrinsic and extrinsic aging processes contribute to aesthetic changes.
Advances in the understanding of skin biology have led to the development of a number of technologies for rejuvenating the skin. Current treatment modalities include ablative and non-ablative lasers, radiofre quency devices, and ultrasound devices 12346789 Recently, HIFU treatment has received proper medical attention as a 'high-tech' way to improve wrinkles and skin laxity 89 This technique combines High Intensity Focused Ultrasound per il cancro alla prostata ultrasound visualization of targeted tissue with the noninvasive delivery of focused ultrasound energy.
Precise microcoagulation zones from the deep dermis to the superficial musculoaponeurotic system SMAS have been demonstrated. These zones cause gradual tightening of the skin through collagen contraction and remodeling To date, few articles have demonstrated the efficacy of HIFU skin-tightening devices.
InAlam et al. Another recent study showed that HIFU could also be used safely and effectively to improve the skin texture and contour of the upper arms, extensor knees, and medial thighs High Intensity Focused Ultrasound per il cancro alla prostata In addition, Suh et al. Unlike in previous studies, we divided the face into seven areas supraorbital, zygomatic, infraorbital, perioral, cheek, preauricular, and jawline and then evaluated each part after HIFU treatment. In this study, regardless of the number of treatment shots, physicians' evaluations and patients' satisfaction with the clinical effects of HIFU seemed similar in all areas.
Improvement was prominent after 3 months and High Intensity Focused Ultrasound per il cancro alla prostata a gradual decrease with time. The top 3 areas with the highest scores were slightly different in the physicians' evaluations and patients' satisfaction scores, which were the jawline, cheek, and perioral areas in decreasing order for physicians' evaluations, and the jawline, perioral, and cheek areas in decreasing order for patients' satisfaction.
Therefore, subjective satisfaction was sustained for at least 6 months. Also, we observed continuous efficacy in the physicians' evaluation on the zygomatic, infraorbital, cheek, and jawline areas. A remarkable finding was that the evaluation by the clinicians and the patients' satisfaction concerning the efficacy of HIFU in each facial area were similar at all time points.
However, patients' satisfaction was higher relative to the evaluation by High Intensity Focused Ultrasound per il cancro alla prostata. This may be because HIFU not only resulted in facial lifting and improvement of wrinkles but also in improvements in skin tone, facial High Intensity Focused Ultrasound per il cancro alla prostata, and subjective symptoms such as tightness or tension on the skin.
This study has several limitations. First, only a small number of patients were included in this study because of cost issues. Second, this study did not include controls. However, despite these limitations, the present study demonstrated the clinical and adverse effects of a novel HIFU treatment in a real clinical situation.
In conclusion, we performed facial lifting with Ulthera in 20 patients older than 30 years, and observed clinical improvement and patient satisfaction after the treatment. We consider HIFU to be a safe, effective, and noninvasive option for facial lifting and improvement of wrinkles. Further evidence is needed from studies with more patients conducted at multiple institutions. Additionally, there is a need for studies on patient factors associated with different outcomes, appropriate treatment intervals, number of shots used, equipment settings, and the need for combined therapy with other treatments, such as botulinum toxin.
Histologic and molecular approaches are also needed to elucidate the mechanisms underlying changes in the collagen of the dermis to the SMAS layer High Intensity Focused Ultrasound per il cancro alla prostata to microcoagulation zones. National Center for Biotechnology InformationU. Journal List Ann Dermatol v. Ann Dermatol. Published online Dec 7. Find articles by Hyunchul Park.
Find articles by Eunjin Kim. Find articles by Jeongeun Kim. Find articles by Youngsuck Ro. Find articles by Jooyeon Ko. Author information Article notes Copyright and License information Disclaimer. Corresponding author. Tel:Fax:rk. Abstract Background High-intensity focused ultrasound HIFU treatment has recently emerged in response to the increasing demand for noninvasive procedures for skin lifting and tightening.
Objective This study was aimed at evaluating the clinical efficacy of and patient satisfaction with HIFU treatment for wrinkles and laxity in seven different areas of the face in Asian skin.
Results The physicians' evaluation and patients' satisfaction with the clinical effects of HIFU in each area were similar regardless of the number of treatment shots.